Results for 'translational research'
Pai, Rekha
Advances in basic research in oncology in 2020: Bridging basic science and clinical care
advances, research, oncology, PCAWG, 2020
Cancer research is advancing with an understanding of the disease at the genetic level, facilitated by massive parallel sequencing. The pan-cancer analysis of the whole genome (PCAWG) in 2020 documented genomic changes across 38 cancer types, involving 2658 cancer genomes. An average of four to …
Mar 24th • 1 min read
Dean Bottino, Rachael Liu, Hojjat Bazzazi, Karthik Venkatakrishnan
Quantitative Translation in Immuno-Oncology Research and Development
Quantitative Translation, Immuno-Oncology, Research, Development, CIC
Exploring the therapeutic potential of the rapidly expanding field of immuno-oncology (IO) drug targets and diverse therapeutic modalities. Recognizing the need for principled decisions based on biologically sound quantitative translation in a competitive clinical research environment. High…
Jul 9th • 3 mins read
Muneera Al Hussain
Comment on: Oncology research in Saudi Arabia over a 10-year period. A synopsis
oncology research, saudi arabia
An article in the Saudi Medical Journal by Alghamdi et al reported on oncology research progress in Saudi Arabia. The study compared research quantity and quality between two periods: 2008-2012 and 2013-2017. There was an increase in the amount of research over time, but quality and scienti…
Jun 24th • 3 mins read
Diana Romero
Research Highlights In The News From ESMO
ESMO, cancer treatment optimization, NICHE-2 trial, SWOG S1801 trial, IPSOS trial, oncology research
The ESMO 2022 Congress took place in Paris in September 2022, with around 29,000 delegates, including 5,000 online participants. The program featured a broad range of topics, including clinical trial results, translational studies, and health policy initiatives. A key theme discussed was…
Sep 30th • 10 mins read
Sarah M. Dermody, Andrew G. Shuman
Implications of Research Biopsies in Clinical Trials
biopsies, clinical trials, oncology
Increased interest in noninvasive testing for treatment monitoring, tumor burden estimation, and disease recurrence prediction. Lower-risk research specimens and liquid biopsies (blood, saliva, urine) offer alternatives to invasive biopsies. Liquid biopsies present new privacy and risk considera…
Aug 31st • 2 mins read
Stephanie Faucette, Santosh Wagh, Ashit Trivedi, Karthik Venkatakrishnan, Neeraj Gupta
Reverse Translation of US Food and Drug Administration Reviews of Oncology New Molecular Entities Approved in 2011-2017: Lessons Learned for Anticancer Drug Development
clinical pharmacology, FDA reviews, PMR, PMC, molecular entitites, anticancer drug development
The article discusses optimizing oncology drug development, focusing on the impact of pharmacokinetic factors like food effects and drug interactions. It recommends early evaluation of these factors to enhance dosing accuracy and patient compliance. Advanced modeling and simulation are suggested to …
Mar 11th • 15 mins read