Temporary Associate Research Scientist

Position Overview
We are seeking a Research Associate to support early-stage small molecule discovery programs through the development, optimization, and execution of biochemical and biophysical assays. This role will contribute to hit identification, hit validation, mechanism-of-action studies, and lead optimization efforts by developing robust assay platforms and supporting high-throughput screening (HTS) activities.

The ideal candidate will have hands-on experience with assay development, screening technologies, laboratory automation, and small molecule research in a fast-paced discovery environment.

Key Responsibilities

- Develop, optimize, and execute biochemical and biophysical assays to support small molecule discovery programs.
- Design and perform high-throughput screening (HTS) campaigns and compound profiling studies.
- Develop assays to support hit identification, hit validation, mechanism-of-action investigations, and lead optimization activities.
- Evaluate and implement new technologies, workflows, and laboratory methods to improve screening and assay performance.
- Analyze, interpret, and communicate experimental results to project teams and stakeholders.
- Prepare technical reports, presentations, and maintain accurate laboratory documentation.
- Collaborate with cross-functional research teams to support project objectives and timelines.
- Follow laboratory safety procedures and maintain compliance with established research practices.


Required Qualifications

- Bachelor's degree in a scientific discipline with 5+ years of relevant experience; Associate degree with 7+ years of experience; or an equivalent combination of education and experience.
- Hands-on experience with biochemical and biophysical assay development for small molecule research.
- Experience developing and executing high-throughput screening assays and screening campaigns.
- Experience working with microplate-based assay formats and compound profiling workflows.
- Strong data analysis, problem-solving, and scientific interpretation skills.
- Excellent written and verbal communication skills.
- Ability to manage multiple priorities and work effectively in a collaborative research environment.


Preferred Qualifications

- Experience with biophysical characterization techniques such as Surface Plasmon Resonance (SPR), Bio-Layer Interferometry (BLI), Microscale Thermophoresis (MST), thermal shift assays, or similar technologies.
- Experience with biochemical assay platforms including AlphaLISA, HTRF, ELISA, MSD, fluorescence polarization, luminescence-based assays, or related methods.
- Experience developing assays in high-density screening formats.
- Experience using laboratory automation platforms, including liquid handlers, dispensers, and automated detection systems.
- Experience supporting mechanism-of-action studies and small molecule characterization.
- Familiarity with targeted protein degradation, molecular glues, heterobifunctional molecules, or related therapeutic approaches.


Key Competencies

- Strong assay development and experimental design skills.
- Experience with high-throughput screening technologies and workflows.
- Strong analytical thinking and attention to detail.
- Ability to troubleshoot assays and optimize experimental performance.
- Effective communication and collaboration skills.
- Ability to work independently while contributing to multidisciplinary project teams.
- Adaptability and ability to thrive in a dynamic research environment.


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Full-time employees are also eligible for benefits options such as health coverage, life insurance, disability insurance, and 401k benefits.

At Advanced Group, our commitment to diversity and inclusion in every part of our organization is crucial to fulfilling our mission and demonstrating our REAL values. Advanced Group is committed to providing employment opportunities without regard to sex, race, color, age, national origin, religion, gender identity or expression, sexual orientation or sexual preference, pregnancy or maternity, genetic information, marital status, disability, veteran status, or any other basis protected by applicable federal, state or local law.

Advanced Group complies with federal and state disability laws and makes reasonable accommodations for applicants and candidates with disabilities. If a reasonable accommodation is needed to participate in the job application or interview process, please contact accommodationrequest@advancedgroup.com.