Scientist-Cell Biology and Assay Development

• Cell-based assay development and execution: Experience developing, optimizing, troubleshooting, and running assays is one of the strongest indicators of fit.

• Advanced application of mammalian cell culture: Look for candidates who have used mammalian cell systems as part of assay development, biological investigation, screening, or compound testing—not candidates whose experience is limited to routine cell maintenance.

• Imaging experience: Hands-on imaging capabilities are highly desirable and considered one of the team’s core technical needs.

• Compound testing / drug-discovery-oriented work: Experience testing compounds or working with assays applicable to drug discovery is particularly valuable.

• Additional relevant techniques: Plate-based assays, flow cytometry, cell-line development, reagent development, and related cell-based research techniques are beneficial.

• Experimental troubleshooting: Candidates should be able to work through technically difficult experiments and scientific problems rather than only execute established protocols.

• Scientific research capability: The team values candidates who understand experimental design, data interpretation, and how individual experiments contribute to a larger scientific question.

Key Responsibilities
• Culture, maintain, and manipulate mammalian cell lines using rigorous cell-culture practices.
• Generate and characterize engineered cell lines using transfection, viral transduction, genome editing, and stable-cell-line selection.
• Develop, optimize, and execute plate-based cell assays for compound screening, hit validation, target engagement, protein modulation, mechanism of action, and cellular health.
• Apply appropriate assay formats, including luminescence-based reporter assays, complementation assays, flow cytometry, immunofluorescence/imaging, western blotting, qPCR, and other fit-for-purpose cellular methods.
• Support imaging-based experiments and quantitative image analysis when needed.
• Plan experiments independently, troubleshoot technical issues, maintain detailed records, analyze data, and communicate results clearly to the broader project team.
• Contribute to the evaluation and prioritization of compounds across multiple early-discovery programs.

Basic Qualifications
• PhD in cell biology, molecular biology, biochemistry, chemical biology, or a related discipline; or
• MS degree in a related discipline with 3–4 years of relevant industry or academic research experience.

Preferred Qualifications
• Recent, hands-on mammalian cell culture experience.
• Demonstrated experience with cell engineering, including transient transfection, lentiviral transduction, and generation of stable cell lines.
• Experience developing and running plate-based cellular assays.
• Experience with protein-degradation, target-engagement, or mechanism-of-action studies is strongly preferred.
• Experience with fluorescence or high-content imaging, image analysis, flow cytometry, antibody staining, and immunofluorescence.
• Familiarity with western blotting, qPCR, reporter assays, and high-throughput or medium-throughput compound testing.
• Ability to independently prioritize day-to-day experimental work, generate high-quality data, and troubleshoot without frequent supervision.
• Strong written and verbal communication skills,