At AstraZeneca, we are committed to turning scientific innovation into life-changing medicines for patients. The US Medical Director – Immunology plays a pivotal role in shaping and advancing the US medical strategy for immunology in systemic lupus erythematosus (SLE) and upcoming lifecycle management indications, including systemic sclerosis (SSc), cutaneous lupus erythematosus (CLE), lupus nephritis (LN), and idiopathic inflammatory myopathies (IIM). Reporting to the US Medical Head, Immunology, this role is a core member of the US Medical Team Immunology and will help define the scientific narrative, evidence generation plans, launch readiness activities, and scientific communications strategy in the US. This is a highly visible, cross-functional leadership opportunity that will directly influence how scientific data is translated into meaningful medical impact for clinicians, patients, and the broader healthcare community. Key Responsibilities In this role, you will: Co-shape and execute US medical strategy for lifecycle management, ensuring alignment with broader business and medical priorities. Develop and communicate the US scientific narrative across indications, translating complex clinical and scientific data into clear, accurate, and compliant strategies and materials. Support launch readiness for lifecycle indications, including scientific platform development, congress planning, internal training, scientific response planning, and medical information preparedness. Partner on evidence generation strategy, including real-world evidence (RWE), health economics and outcomes research (HEOR), externally sponsored research (ESRs), publication planning, and congress activities. Contribute to external scientific engagement plans with key experts, institutions, professional societies, and other stakeholders in a compliant and strategic manner. Provide medical review and scientific input for publications, training materials, FAQs, and promotional and non-promotional content in collaboration with cross-functional teams. Deliver scientific and clinical training for Field Medical teams and internal stakeholders to build readiness across lifecycle priorities. Collaborate closely with global teams to ensure US insights and needs are reflected in global medical and development plans. Ensure full compliance with FDA, OPDP, PhRMA, and AstraZeneca policies, standards, and ways of working. Champion innovative and AI-enabled ways of working to improve efficiency and enhance medical impact. Must-Have Qualifications To succeed in this role, you should bring: An advanced degree such as MS, MD, PhD, or PharmD. A minimum of 5 years of experience in medical affairs, clinical development, and/or lifecycle management within the pharmaceutical, biotechnology or academic sectors; or a minimum of 5 years of experience of direct patient care in academic or clinical setting. Strong expertise in immunology, rheumatology, autoimmune disease, or a closely related therapeutic area. Solid understanding of the US regulatory and compliance environment, including FDA and OPDP requirements. Experience contributing to evidence generation, RWE/HEOR, publications, congress strategy, and scientific communications. Demonstrated ability to work effectively in a cross-functional matrix environment and align US and global medical priorities. Excellent scientific communication, presentation, and stakeholder engagement skills. The ability to translate complex scientific information into clear, compelling, accessible, and compliant messages for diverse audiences. Strong judgment, collaborative leadership, and a commitment to high ethical standards. Willingness and ability to travel within the US and occasionally internationally. Desirable Qualifications The following would be advantageous: Prior experience supporting launch readiness for new indications or lifecycle expansion opportunities. Experience working across multiple stakeholder groups, including Medical, Commercial, Clinical Development, Regulatory, Market Access/HEOR, Medical Information, and Patient Safety. Familiarity with building or refining scientific platforms and medical response strategies. Experience engaging with external experts, institutions, and professional societies in a compliant scientific exchange setting. Interest in or experience with innovative and AI-enabled approaches to improve medical affairs effectiveness and execution. Why Join AstraZeneca? This is an opportunity to make a meaningful impact in a role that sits at the intersection of science, strategy, and patient care. You will work with talented cross-functional teams, help shape the future of Saphnelo across important lifecycle indications, and contribute to scientific advancements that can improve outcomes for patients living with serious immunologic diseases. If you are a scientifically strong, collaborative, and strategic medical leader who thrives in a dynamic environment, we encourage you to apply and bring your expertise to a team committed to changing patients’ lives through science. The annual base pay for this position ranges from 193,281.60 - 289,922.40 USD annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. Date Posted 18-Jun-2026 Closing Date 30-Jun-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.