Job Description

Are you a visionary scientist with a passion for oncology and translational research? Do you thrive at the intersection of discovery and clinical development? We are seeking a strategic and scientifically rigorous Translational Medicine Lead to advance programs and drive innovation in our oncology pipeline. This is an exceptional opportunity to join a purpose-driven company and play a foundational role in building translational capabilities that will impact the future of oncology therapies.

This is a high-impact individual contributor role with matrix leadership responsibility. This individual collaborates across internal and external stakeholders to integrate translational science into research and clinical development, driving translational research, clinical biomarkers, companion diagnostics, and biomarker-enabled decision making.

This position reports to VP Global Translational Medicine as an individual contributor. You can be based in Cambridge, MA, US or Cambridge, UK (Hybrid work according to Orion's policy).

Key Responsibilities

• Lead and own Translational Medicine strategy for one or more oncology programs across research to clinical development, with a focus on biomarker development, patient enrichment, companion diagnostics, proof of mechanism and resistance insights.
• Subject matter expert in solid tumor biology, disease progression and treatment options; accountable for the strategic design and oversight of implementation of Biomarker strategies associated with disease context and drug modalities
• Serve as the bridge between discovery research and clinical development; providing critical input in developing translational strategies to bring new agents to the clinic.
• Ensure translational insights are embedded into study trial design and conduct
• Serve as the single accountable Translational Medicine representative within the Global Project Team
• Partnering with internal and external collaborators to deliver clinically validated biomarker assays into clinical studies.
• Collaborate closely with CDx lead, translational biology lead, regulatory and commercial to advance companion diagnostic development and regulatory approval
• Deliver timely, high-quality biomarker data and integrated insights to accelerate program decision-making
• Lead reverse translation via the continuous learning from patients’ data to generate insights that can be back translate to research and early development.
• Lead l Translational Medicine matrix teams across research, translational pharmacology, clinical development, Bioinformatics, Translational Biology, CDx and QSP Lead.
• Ensure the appropriate evaluation of state-of-the art platform technologies and incorporating innovative biomarkers into translational medicine plans.
• Contribute to IND, CTA, and regulatory submissions, ensuring translational strategies support successful approvals.

What You Can Expect From Us

At Orion Pharma, your work impacts millions of lives around the world. With us, you get to work on challenges that matter and see the difference your work makes every day. We believe our people are the key to our success, which is why we invest in your continuous learning.

Our innovative products are world-class, and we take sustainability and ethics seriously. Rooted in our Nordic heritage, we value teamwork, low hierarchies, and a culture where every voice is heard.

We are builders of well-being and offer jobs with a clear purpose: helping people live their lives to the fullest.

Please visit our website to find further information about our values and Orion as an employer: https://www.orionpharma.com/careers/working-with-us/

What are we looking for?

Basic Qualifications

• Ph.D. or equivalent advanced degree in biological sciences or related
• 5+ years relevant translational experience within biotech/pharma
• Strong experience in clinical biomarkers and translational strategy execution
• Experience in oncology drug development
• Proven experience in matrix leadership and cross-functional delivery

Preferred Qualifications

• Deep expertise in cancer biology and treatment landscape
• Deep Experience integrating clinical omics data into development decision making
• Hands-on experience across modalities (e.g. small molecules, ADCs, IO, cell therapies)
• Demonstrated experience with CDx strategy and regulatory pathways
• Strong ability to influence senior stakeholders and drive decisions in a matrix environment

Travel Requirements

• Ability and willingness to travel internationally as required

How To Apply

Please send your application with the latest CV and cover letter by July 26th, 2026.

The expected annual salary range for this position is USD 130,000–300,000 for U.S.-based candidates, depending on skills, experience, and job-related qualifications. For UK-based candidates, compensation will be aligned with Orion’s salary range for the applicable grade.

We typically review applications already during the application period and may start interviewing candidates before the application deadline. Therefore, we invite you to send your application as soon as possible.

Orion Pharma’s pharmaceutical innovations are created within its R&D organization. We employ around 400 top professionals in the field of drug discovery and development. We work globally: in Espoo and Turku in Finland, in Cambridge and Nottingham in England and in Cambridge, MA, US. Orion R&D and the Innovative Medicines business division are dedicated to making a transformation to become a global player in the pain and oncology therapy areas.

About Us

Orion Pharma is a globally operating Nordic pharmaceutical company – a builder of well-being for over a hundred years.

We’re home to more than 4,000 Orionees around the world, and we’re proud to be known as a responsible employer and a great place to work. At Orion Pharma, people are truly valued and trusted, encouraged to grow, and supported by a culture where every voice is heard. We appreciate each other, strive for excellence, and build the future.

Together we develop, manufacture, and market human and veterinary pharmaceuticals and active pharmaceutical ingredients. Our extensive portfolio includes proprietary and generic medicines as well as consumer health products. The core therapy areas of our pharmaceutical R&D are oncology and pain. Proprietary products developed by Orion Pharma are used to treat cancer, neurological diseases, respiratory diseases, and more.

We offer careers with a clear purpose: empowering people to live their lives to the fullest.