Thoracic Oncology Medical Director, Clinical Science

Location: Northern

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Medical Director, Clinical Science – Thoracic Oncologyence in our Cambridge office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

The Medical Director, Clinical Science – Thoracic Oncology provides medical and scientific leadership for the design, execution and interpretation of global clinical studies within Takeda’s thoracic oncology portfolio, spanning non-small cell lung cancer, small cell lung cancer and other intrathoracic malignancies.

Reporting to the Executive Medical Director, Oncology Clinical Sciences, the role partners with the Clinical Development lead to translating program strategy into high-quality protocols, robust data and regulatory-grade deliverables that advance assets from first-in-human through registrational studies and lifecycle expansion.

The role is a core contributor to the clinical evidence that underpins health authority interactions (FDA, internal governance reviews and serves as a credible scientific voice with investigators and external experts in the thoracic oncology community.

Scope
• Supports one or more global thoracic oncology assets and their associated Phase 1–3 studies; scope of studies assigned scales with demonstrated capability.
• Geographic: Global – studies conducted across North America, Europe, Japan and Asia‑Pacific, including partnered and alliance-run trials.
• People: Individual contributors. lead through influence within global study teams and may mentor junior clinical scientists and physicians.
• Financial: Contributes to study budget planning and vendor oversight in partnership with Clinical Operations and Program Management; no independent budget accountability.

Accountabilities
• Contribute medical and scientific input to the clinical development plan and strategy for assigned thoracic oncology study.
• Support dose selection and optimization strategy consistent with FDA Project Optimus expectations, working with Clinical Pharmacology, Translational Medicine, and Biostatistics.
• Provide clinical input into biomarker and patient-selection strategies, including histology and PD‑L1‑based subgroup considerations, and into stratification and multiplicity assumptions.
• Maintain current competitive and scientific landscape intelligence for thoracic tumors and translate it into implications for study design and timing.
• Author or co-author with clinical study protocols, amendments, informed consent templates, investigator brochures and clinical study reports.
• Serve as a medical monitor or deputy medical monitor: eligibility adjudication, protocol deviation review, dose-modification guidance and site medical support.
• Partner with Clinical Operations and CROs on feasibility, site selection, enrollment strategy and risk…