Senior Scientist, Muscle Biology

Soufflé Therapeutics is a biotech company focusing on the cell-type specific delivery of genetic medicines. It's team of driven scientists is making a mark in delivery of oligonucleotides to extrahepatic tissues. We thrive in a purpose-building lab and office space in Watertown. Come and join us in our quest!





Position Summary:

As Soufflé's phospholamban program advances toward the clinic, we're seeking a Senior Scientist to lead nonclinical efficacy and pharmacology studies, both internally and with external academic and CRO collaborators. This is a new role created to give the program dedicated bandwidth for in vivo, cellular, and organoid models of cardiac disease, including expansion into new indications and novel model systems.





Key Responsibilities


- Independently lead and execute in vivo and in vitro studies supporting the phospholamban program
- Own downstream processing, analysis, and data presentation for cardiac/muscle studies
- Serve as the main point of contact for external collaborator relationships, including academic leaders and CROs
- Mentor and train other scientists on novel assays and functional assessments
- Support biology assessment of novel cardiac targets






What Success Looks Like


- In 3 months: Completed sample analysis and interpretation for ongoing external collaborator studies, and established as the primary point of contact for those collaborations and internal study lead
- In 6 months: Demonstrated lab leadership as primary mentor to an associate scientist, and completed assessment of cardiac organoid platforms to support development of siRNA conjugates
- In 12 months: Developed a strategy for functional evaluation in expansion indications such, and identified go/no-go decision points and critical studies for exploratory cardiac targets






Qualifications — Required


- 3-6+ years of relevant industry experience, including 2+ years in a similar role, with a PhD or Master's degree and significant experience in cardiac or muscle biology
- Hands-on experience with cardiac-specific disease models and functional assessments (e.g., hypertrophy analysis, contractility, calcium assessments), and standard lab techniques (qPCR, western blotting, cell culture, necropsy, tissue processing and analysis)
- Experience designing in vivo and in vitro pharmacology/efficacy studies and leading external collaborations with CROs or academic partners
- Strong team player with high emotional intelligence and communication skills, comfortable in a fast-paced startup environment with competing, shifting priorities






Qualifications — Preferred


- Experience with heart failure specifically, cardiac organoids or ex vivo cardiac models, and/or exposure to nonclinical development






Education


- PhD or Master's degree, with significant experience and exposure to cardiac or muscle biology






At Soufflé Therapeutics, we are intentional about building an equitable culture. How we treat our people is reflective of this focus. We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.





This is an onsite position in Watertown, MA (US) with flexibility as needed for collaboration and external engagements.