About the Role Our client, a cutting-edge biotechnology company focused on developing novel cancer therapies, is seeking a talented and experienced Senior Medicinal Chemist to join their dynamic research team in **Durham, North Carolina**. This role is central to the design, synthesis, and optimization of small molecule drug candidates targeting oncogenic pathways. The ideal candidate will possess a strong foundation in organic synthesis, a deep understanding of structure-activity relationships (SAR), and a passion for medicinal chemistry applied to oncology. You will work collaboratively within a multidisciplinary team of biologists, pharmacologists, and computational chemists to advance promising leads through the discovery pipeline. This is a remarkable opportunity to contribute to the development of potentially life-saving treatments in a scientifically stimulating environment located in the heart of **Durham, North Carolina**'s Research Triangle Park. The Senior Medicinal Chemist will be a key contributor to the innovation and success of the oncology program. Key Responsibilities Design and synthesize novel small molecule compounds with potential anti-cancer activity. Optimize lead compounds to improve potency, selectivity, pharmacokinetic properties, and safety profiles. Develop and execute synthetic routes for target molecules, troubleshooting challenges as they arise. Collaborate with biologists and pharmacologists to test and evaluate synthesized compounds. Analyze and interpret SAR data to guide iterative design-make-test-analyze cycles. Utilize computational chemistry tools and databases to inform compound design. Stay abreast of the latest advancements in medicinal chemistry, organic synthesis, and cancer biology. Contribute to patent filings and scientific publications. Mentor junior chemists and contribute to the overall scientific direction of the team. Manage project timelines and contribute to strategic planning for discovery programs. Requirements Ph.D. in Organic Chemistry or Medicinal Chemistry. Minimum of 5 years of postdoctoral or industry experience in medicinal chemistry, preferably in oncology drug discovery. Demonstrated expertise in synthetic organic chemistry and a proven track record of designing and synthesizing complex molecules. Strong understanding of SAR principles and experience in iterative lead optimization. Familiarity with drug discovery processes and multidisciplinary team collaboration. Experience with common analytical techniques (NMR, LC-MS, HPLC) for compound characterization. Excellent problem-solving skills and creativity in synthetic design. Strong written and oral communication skills. Ability to work independently and as part of a collaborative team. Benefits Competitive salary, bonus potential, and stock options. Comprehensive medical, dental, and vision insurance coverage. Generous 401(k) retirement plan with company match. Paid time off, including vacation, holidays, and sick leave. Opportunities for professional development, conferences, and training. A vibrant and collaborative research environment in **Durham, North Carolina**. Relocation assistance may be provided for exceptional candidates. Chance to work on groundbreaking therapies in a growing field.