Damora Therapeutics is an innovative biotechnology company that aims to fundamentally redefine care for people with hematologic disorders. We are advancing a new generation of biologics to treat mutant calreticulin‑driven myeloproliferative neoplasms, including essential thrombocythemia and myelofibrosis, where there is significant medical need for new disease‑modifying treatments. With multiple programs with best‑in‑class potential on track to enter clinical development in 2026, our goal is to rapidly bring forward optimized treatments with broad mutation coverage and exceptional convenience to dramatically improve patient outcomes.
The Role

This is a unique opportunity to join a science‑driven company at a formative stage, where early clinical data will directly shape development strategy and drive long‑term value. The right candidate will join a team with significant early‑ and late‑stage development experience, with the goal of quickly moving through dose escalation/expansion into pivotal trials.

The Senior Director, Clinical Pharmacology will lead Damora’s clinical pharmacology strategy and execution across all development programs and guide dose optimization, exposure–response modeling, and clinical pharmacology components of regulatory submissions. This role will work closely across development functions to shape integrated, forward‑looking clinical development plans that support efficient and thoughtful program advancement.
Responsibilities
• Develop and execute clinical pharmacology strategies across all stages of drug development
• Drive the integration of PK, PD, safety, and efficacy data to inform dose selection, dose modification, and labeling recommendations
• Author and review clinical pharmacology sections of INDs, protocols, IBs and global submissions
• Represent clinical pharmacology in interactions with FDA and other global regulators, as required
• Partner closely with Clinical Development, Biostatistics, Regulatory Affairs, Translational Sciences, CMC and Bioanalytical teams serving as an subject matter expert in cross‑functional discussions to ensure cohesive end‑to‑end development plans
• Lead population PK (PopPK), PK/PD, exposure–response, and disease modeling analyses to inform clinical drug development using model‑based approach
• Stay current with global regulatory expectations for biologics to contribute to cross‑functional strategy
• Oversee CROs and external modeling vendors as needed
• Demonstrated ability to collaborate across matrixed, cross‑functional teams in a fast‑paced environment
• Proven ability to manage multiple projects simultaneously with attention to timelines and detail
• Strong communication and interpersonal skills; build trust and foster relationships internally and externally
• Able to work independently, take initiative, and adapt quickly to evolving priorities.
• Recognized leader who exhibits effective communication, emotional intelligence, and influencing skills, within a matrix operating environment
• Demonstration of strategic thinking and high‑level planning while also balancing the ability to manage and execute operational details
• Experience designing clinical pharmacology and pharmacometrics components of filing packages and clinical studies across all phases
• Experience with regulatory agency interactions including written responses and IND/CTA packages
Qualifications
• PhD, PharmD, or MD in Clinical Pharmacology, Pharmacometrics, Pharmaceutical Sciences, Pharmacology, Translational Medicine, or related discipline with 10+ years of experience, OR
• Master’s Degree (or equivalent degree) in Clinical Pharmacology, Pharmacometrics, Pharmaceutical Sciences, Pharmacology, Translational Medicine or related discipline with 15+ years of relevant experience in biopharma
• Prior experience with biologics development required.
• Experience in preclinical to Phase 1 stage programs required. Late‑stage clinical development experience preferred
• Experience in oncology/hematology strongly preferred
Benefits

At Damora Therapeutics, we offer competitive compensation and thoughtfully designed total rewards aligned with industry benchmarks. We believe in rewarding impact and building meaningful ownership for our team.
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