Senior Computational Scientist - Systems Biology & NextGen Data Engineering
Calliere · Union City, CA
FULL-TIME
Job Description
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Step into a role where code meets clinical impact. We're building the next generation of datadriven diagnostics - at the intersection of biology, computation, and machine learning. You'll join a tight\-knit team of scientists and engineers decoding huge multiomic datasets to uncover patterns that actually change patient outcomes.
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What You'll Do
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• Architect and optimize computational pipelines that turn raw highresolution molecular data into clean, interpretable insights.
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• Apply advanced statistical and algorithmic frameworks to analyze ultralarge celllevel and spatial datasets.
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• Design and validate novel biomarkers and molecular signatures that accelerate diagnostic innovation.
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• Maintain scalable, reproducible data workflows capable of handling cohorts of hundreds or thousands of biological samples.
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• Partner with biologists, data scientists, and software engineers to push new ideas from concept to clinical utility.
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Requirements<\/h3>
What You Bring
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• Ph.D. (or equivalent experience) in computational biology, bioinformatics, genomics, or a quantitative discipline.
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• 5+ years working handson with singlecell, spatial, or highthroughput sequencing data.
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• Deep understanding of algorithmic performance, statistical rigor, and how analytical assumptions translate to biological meaning.
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• Strong engineering mindset - you write clean, extensible code that scales gracefully.
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• Expertlevel fluency in Linux and modern programming ecosystems.
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• Independent drive, intellectual curiosity, and relentless attention to detail.
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Bonus Points For
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• Experience with nextgeneration spatial or singlecell assay platforms.
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• Background in oncology, immunology, or systemslevel disease research.
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<\/li>
• Familiarity with biomarker discovery pipelines or clinical data integration.
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<\/li>
• Machine learning or statistical modeling applied to multiomic data.
<\/p>
<\/li>
• Practical experience with workflow orchestration (Nextflow, Snakemake, or similar).
<\/p>
<\/li>
• Solid software engineering habits - reproducible analysis, version control, peer review, and testing.
<\/p>
<\/li>
• Comfort operating in highperformance or cloud computing environments.
<\/p>
<\/li>
<\/ul>
If you're driven by the idea of building tools that help decode biology at scale and you thrive where data meets diagnostics, this is your stage.
<\/p>
<\/div>
<\/span>
<\/body>
<\/html>
Step into a role where code meets clinical impact. We're building the next generation of datadriven diagnostics - at the intersection of biology, computation, and machine learning. You'll join a tight\-knit team of scientists and engineers decoding huge multiomic datasets to uncover patterns that actually change patient outcomes.
<\/p>
What You'll Do
<\/h2>
• Architect and optimize computational pipelines that turn raw highresolution molecular data into clean, interpretable insights.
<\/p>
<\/li>
• Apply advanced statistical and algorithmic frameworks to analyze ultralarge celllevel and spatial datasets.
<\/p>
<\/li>
• Design and validate novel biomarkers and molecular signatures that accelerate diagnostic innovation.
<\/p>
<\/li>
• Maintain scalable, reproducible data workflows capable of handling cohorts of hundreds or thousands of biological samples.
<\/p>
<\/li>
• Partner with biologists, data scientists, and software engineers to push new ideas from concept to clinical utility.
<\/p>
<\/li>
<\/ul>
<\/div>
<\/span>
Requirements<\/h3>
What You Bring
<\/h2>
• Ph.D. (or equivalent experience) in computational biology, bioinformatics, genomics, or a quantitative discipline.
<\/p>
<\/li>
• 5+ years working handson with singlecell, spatial, or highthroughput sequencing data.
<\/p>
<\/li>
• Deep understanding of algorithmic performance, statistical rigor, and how analytical assumptions translate to biological meaning.
<\/p>
<\/li>
• Strong engineering mindset - you write clean, extensible code that scales gracefully.
<\/p>
<\/li>
• Expertlevel fluency in Linux and modern programming ecosystems.
<\/p>
<\/li>
• Independent drive, intellectual curiosity, and relentless attention to detail.
<\/p>
<\/li>
<\/ul>
Bonus Points For
<\/h2>
• Experience with nextgeneration spatial or singlecell assay platforms.
<\/p>
<\/li>
• Background in oncology, immunology, or systemslevel disease research.
<\/p>
<\/li>
• Familiarity with biomarker discovery pipelines or clinical data integration.
<\/p>
<\/li>
• Machine learning or statistical modeling applied to multiomic data.
<\/p>
<\/li>
• Practical experience with workflow orchestration (Nextflow, Snakemake, or similar).
<\/p>
<\/li>
• Solid software engineering habits - reproducible analysis, version control, peer review, and testing.
<\/p>
<\/li>
• Comfort operating in highperformance or cloud computing environments.
<\/p>
<\/li>
<\/ul>
If you're driven by the idea of building tools that help decode biology at scale and you thrive where data meets diagnostics, this is your stage.
<\/p>
<\/div>
<\/span>
<\/body>
<\/html>
Additional Details
- City
- Union City
- State
- California
- Country
- US
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