Scientist II, Translational Science

ModeX Therapeutics is seeking a highly skilled and motivated Scientist II to support the development and execution of biomarker strategies across early-stage clinical programs. The successful candidate will contribute to the design, implementation, and interpretation of biomarker studies that inform mechanism of action, patient selection, pharmacodynamic activity, and clinical development decisions.
The position requires previous experience in Immuno-Oncology and multi-parameter flow cytometry analysis; experience in Clinical Biomarkers is preferred. Key responsibilities of the role will be to analyze biomarker data from several clinical studies, updating and managing biomarker datasets, and carry out translational in vitro studies to support biomarker discovery and method development. As a Translational Scientist, you will help generate critical translational insights that advance therapeutic programs from early clinical development through proof-of-concept, enabling data-driven decisions that improve patient outcomes and accelerate drug development.
This is an exciting opportunity to be part of a cross-functional team and contribute to the development of next-generation therapeutics in a fast-paced, rapidly growing biotech company with a bold vision.
Key Responsibilities
Support the development and execution of clinical biomarker plans for ModeX’s clinical studies.
Contribute to the selection, validation, and implementation of biomarker assays, including flow cytometry, immunophenotyping, cytokine analyses, soluble biomarkers, genomics, transcriptomics, and tissue-based assays.
Monitor biomarker sample quality, assay performance, and data delivery timelines.
Manage activities and deliverables of external laboratories, CROs, and academic collaborators.
Perform biomarker data review, analysis, interpretation, and visualization to support study objectives and decision-making.
Integrate biomarker, clinical, pharmacokinetic (PK), and safety data to generate biological insights.
Prepare biomarker data summaries, reports, presentations, and study team updates.
Maintain awareness of emerging biomarker technologies, therapeutic area trends, and translational research advances.
Perform translational science studies to support IND-enabling studies, accelerate biomarker discovery, and contribute to the advancement of various preclinical and clinical programs
Qualifications
PhD in Immunology or a related field
2 – 5+ years of highly relevant work experience in Immunology, preferably Immuno-Oncology and T cell biology, with good track record from industry or academia
Experience supporting biomarker activities in clinical development is preferred.
Hands-on experience in immune cell assays and multi-parameter flow cytometry. Experience with antibody-based therapeutics is a plus
Ability to interpret and communicate complex biological datasets.
Proficiency with data analysis and visualization tools (e.g., GraphPad Prism, R)
Good written and oral communication, organizational skills, and experience in data generation/analysis.
Outstanding learning ability, troubleshooting and problem-solving skills
Highly adaptable to a fast-paced working environment and capable of working effectively in a team setting as well as individually
ModeX Therapeutics is an Equal Opportunity Employer