Scientist II

The Fountain Group is currently seeking a Scientist II for a prominent client of ours. This position is located in
South San Francisco, CA. Details for the position are as follows:




- Pay: $57-67/hr.
- 12-month assignment with possibility for extension or conversion based on performance and budget.






Responsibilities:





- Design and execute in vitro antibody discovery and display workflows, including phage display and/or yeast display, to support lead antibody identification and optimization.

- Perform molecular cloning, antibody library construction, sequence analysis, and bacterial and yeast culture to generate and evaluate antibody candidates.

- Conduct binding and characterization assays, including ELISA, flow cytometry, and/or SPR, to assess antibody affinity, specificity, and functional properties.

- Apply molecular and cell biology techniques, including mammalian cell culture, to support antibody engineering, optimization, and mechanistic studies.

- Support antibody engineering and optimization, including affinity modulation, humanization, and liability assessment, to improve therapeutic candidate properties.

- Analyze, interpret, and document experimental data using GraphPad Prism, Geneious, and/or Genedata, and contribute to stage-gate appropriate in vitro and in vivo data packages supporting proof-of-concept studies.

- Collaborate with cross-functional research teams to advance biologics discovery programs across therapeutic areas, and communicate findings through technical reports, presentations, and team discussions.






Qualifications:





- BS or MS in Biology or a related field with typically 5+ years of experience (BS) or 2+ years of experience (MS) in a pharmaceutical and/or relevant research environment
- Hands-on experience with in vitro antibody discovery display technologies (e.g., phage display, yeast display)
- Direct experience with binding assays (e.g., ELISA, flow cytometry or SPR)
- Strong molecular and cell biology skills (e.g., molecular cloning, sequence analysis, E coli and/or yeast culture, mammalian cell culture, etc.)
- Familiarity with protein structure, affinity, antibodies and antibody fragments





Preferred Qualifications:





- Experience in antibody engineering and optimization (e.g., affinity modulation, liability engineering, humanization)
- Experience with antibody library design and construction
- Experience in mammalian cell culture and multiplex flow cytometry
- Experience with automation of biologics discovery processes
- Proficiency with Prism, Geneious and/or Genedata
- Excellent oral and written communication skills, including proficiency with MS Office Suite (Excel, PowerPoint, Word)






If you are interested in hearing more about the position, please respond to this posting with your resume attached.



Please forward this posting to any friends or colleagues as we do offer a
Referral Bonus for any candidate hired.



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