About the Role

We are seeking a Principal Scientist to serve as a translational and strategic
leader within our

Oncology research organization. This role sits at the crossroads of reverse
translation, biomarker

science, and cutting-edge genomics technology - driving mechanistic insight from
the clinic

back into discovery to accelerate and de-risk our oncology pipeline. The ideal
candidate brings

deep expertise in cancer biology, a track record of cross-functional leadership
in a pharma or

biotech environment, and hands-on experience building and deploying single cell
and spatial

omics capabilities.

What You'll Do

Discovery & Translational Research Leadership

 Drive discovery and translational projects in collaboration with AI and
internal research

teams with a primary focus on integrating scRNA-seq and spatial biology into
Natera's

pipeline.

 Collaborate with external translational teams on building single-cell and
spatial biology

workflows into their early phase clinical studies.

 Leverage novel technologies to inform collaborative reverse and forward
translation

efforts as well as internal target discovery and validation projects.

 Design and execute lab-based research programs that bridge clinical
observations with

mechanistic hypotheses, supporting asset progression and CDP expansion

Technology & Capabilities

 Lead and contribute to technology area team focused on single cell genomics

omics, building out multiomics capabilities to support foundational models and
RWD

efforts

 Partner with internal and external collaborators to establish, optimize, and
deploy cutting-

edge platforms for translational applications

 Serve as an internal expert and thought leader on emerging genomics
technologies

relevant to oncology drug discovery and development

Cross-Functional & Strategic Engagement

 Represent translational science on life cycle, RWD, and BioPharma BD teams

 Collaborate with Clinical, Biomarker, Discovery, and Regulatory colleagues to
shape

clinical trial design and biomarker plans

 Build and maintain external scientific partnerships and advisory relationships
as

appropriate

People & Team Development

 Lead and mentor a team of scientists and contractors, with a strong commitment
to career

development and scientific growth

 Foster a collaborative, high-performance team culture with clear goals and
accountability

Position Requirements

 Ph. D. in Cancer Biology, Molecular/Cellular Biology, Immunology,
Bioengineering, or a

closely related field

 6+ years of experience post-Ph. D. in oncology translational research within
biotech or

pharma, including demonstrated growth into senior or principal scientist roles

 Deep scientific expertise in at least one of the following: cancer cell
biology, tumor

immunology, cell engineering, or neoantigen biology

 Hands-on experience with single cell genomics, spatial transcriptomics, or
multiomics

platforms; experience building or scaling these capabilities in an
organizational context is

strongly preferred

 Strong publication and/or patent record reflecting independent scientific
contribution

 Demonstrated experience leading cross-functional programs and influencing
without

authority across Research, Clinical, and Biomarker teams

 Prior experience managing and mentoring scientists at multiple career stages

 Exceptional scientific communication skills; ability to synthesize complex
data and

present compellingly to diverse audiences

Compensation & Total Rewards

This range reflects a good-faith estimate of the base pay we reasonably expect
to offer at the time of

hire. Final compensation will vary based on experience,
qualifications, and internal equity considerations.

This position is also eligible for additional compensation and benefits
through Natera's robust Total Rewards program, including:
• Annual performance incentive bonus
• Long-term equity awards
• Comprehensive health benefits (medical, dental, vision)
• 401(k) with company match
• Generous paid time off and company holidays
• Additional wellness and work-life benefits

Compensation Range
$171,900-$214,950 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to
oncology, women's health, and organ health. Our aim is to make personalized
genetic testing and diagnostics part of the standard of care to protect health
and enable earlier and more targeted interventions that lead to longer,
healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists,
doctors, laboratory scientists, business professionals, software engineers and
many other professionals from world-class institutions, who care deeply for our
work and each other. When you join Natera, you'll work hard and grow quickly.
Working alongside the elite of the industry, you'll be stretched and challenged,
and take pride in being part of a company that is changing the landscape of
genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental,
vision, life and disability plans for eligible employees and their dependents.
Additionally, Natera employees and their immediate families receive free testing
in addition to fertility care benefits. Other benefits include pregnancy and
baby bonding leave, 401k benefits, commuter benefits and much more. We also
offer a generous employee referral progr.