Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology; Hematology

Position: Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology)

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life‑threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR‑T), and natural killer (NK) cell‑based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting‑edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta‑cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking a Principal Scientist, Clinical Biomarker, Immunology & Immuno‑Oncology (Hematology) as part of the Early Drug Development team based in Somerset, NJ
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Role Overview

We are seeking a highly motivated and innovative Principal Scientist to join our immunology and immuno‑oncology (IO) clinical biomarker projects, with a dedicated focus on hematological malignancies. In this role, you will drive the clinical translational understanding of novel therapy in hematology. You will serve as the biology lead on cross‑functional project teams, drive MOA of novel cell therapy and clinical biomarker strategy.
Key Responsibilities
• Design, execute, and analyse results from clinical studies to investigate the mechanisms of action for novel IO targets in hematological indications (e.g., AML, DLBCL, Multiple Myeloma).
• Bridge discovery and clinical development by utilising primary human samples and clinical datasets to validate targets and understand the immune microenvironment in hematology.
• Oversee the generation and interpretation of high‑dimensional molecular and cellular data. Leverage advanced single‑cell technologies (e.g., scRNA‑seq) to deeply profile immune cell compartments, particularly T‑cell states and exhaustion markers, to inform patient stratification and biomarker hypotheses.
• Partner closely with other functional teams for better understanding of MOA and foundational immunology.
Requirements
• Ph.D. in Immunology, Immuno‑Oncology, Cellular Biology, or a closely related discipline, with the ability to initiate and lead data‑driven MOA studies. Experience with cell therapy is a plus but not required.
• A minimum of 5‑8+ years of post‑doctoral and/or industry experience in biotech or pharma, with a proven track record of advancing IO programs. Deep understanding of immunology, particularly T cell biology, is highly desirable.
• Deep biological understanding of hematological malignancies and the unique tumour immune microenvironment of the blood and bone marrow.
• Experience working with multi‑dimensional data and extracting biological insights from data is highly desirable.
• Exceptional written and verbal communication skills, with the ability to distil complex data into clear, actionable strategic decisions.
Benefits and Paid Time Off

Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. Eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short‑ and long‑term disability coverage, legal assistance, and…