Principal Clinical Scientist
Alignerr · Chicago, IL
CONTRACT
Posted Sep 7, 2026
Job Description
Principal Clinical Scientist (AI Training)
About The Role
What if your career designing rigorous clinical trials and interpreting regulatory-grade data could directly influence how AI understands medicine? We're looking for a Principal Clinical Scientist to bring senior-level clinical expertise into the development of cutting-edge AI systems — helping ensure these models reason about clinical evidence the way a seasoned scientist would.
This is a fully remote, flexible contract role built for experienced clinical researchers who want to work at the intersection of science and frontier AI. No AI background required — just deep clinical expertise and a sharp eye for scientific rigor.
- Organization: Alignerr
- Type: Hourly Contract
- Location: Remote
- Commitment: 10–40 hours/week
What You'll Do
- Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation
- Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards
- Evaluate AI-generated clinical analyses for scientific soundness and compliance with FDA, EMA, or equivalent agency expectations
- Provide expert feedback that directly shapes how AI models understand, reason about, and evaluate clinical trial data and outcomes
- Flag gaps in methodology, data quality, or regulatory relevance across AI-generated clinical content
Who You Are
- Senior-level clinical researcher with hands-on experience designing trial protocols for regulatory submission
- Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent regulatory bodies
- Strong grounding in clinical research methodology, biostatistics, or translational science
- Naturally rigorous — you hold AI-generated outputs to the same standard you'd apply in a real submission
- Self-directed and comfortable working independently in an asynchronous environment
Nice to Have
- Prior experience with data annotation, data quality evaluation, or AI output assessment
- Background in pharmacology, oncology, rare disease, or another specialized therapeutic area
- Familiarity with ICH guidelines, GCP standards, or regulatory submission frameworks
- Experience working across multidisciplinary research teams
Why Join Us
- Work directly on frontier AI systems that are reshaping how clinical and biomedical research is conducted
- Influence how AI understands and evaluates real-world clinical evidence — at a scale no individual trial could achieve
- Fully remote and flexible — work when and where it suits you
- Freelance autonomy with the structure of meaningful, high-impact, task-based work
- Collaborate with world-leading AI research labs on problems that matter
- Potential for ongoing work and contract extension as new projects launch
About The Role
What if your career designing rigorous clinical trials and interpreting regulatory-grade data could directly influence how AI understands medicine? We're looking for a Principal Clinical Scientist to bring senior-level clinical expertise into the development of cutting-edge AI systems — helping ensure these models reason about clinical evidence the way a seasoned scientist would.
This is a fully remote, flexible contract role built for experienced clinical researchers who want to work at the intersection of science and frontier AI. No AI background required — just deep clinical expertise and a sharp eye for scientific rigor.
- Organization: Alignerr
- Type: Hourly Contract
- Location: Remote
- Commitment: 10–40 hours/week
What You'll Do
- Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation
- Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards
- Evaluate AI-generated clinical analyses for scientific soundness and compliance with FDA, EMA, or equivalent agency expectations
- Provide expert feedback that directly shapes how AI models understand, reason about, and evaluate clinical trial data and outcomes
- Flag gaps in methodology, data quality, or regulatory relevance across AI-generated clinical content
Who You Are
- Senior-level clinical researcher with hands-on experience designing trial protocols for regulatory submission
- Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent regulatory bodies
- Strong grounding in clinical research methodology, biostatistics, or translational science
- Naturally rigorous — you hold AI-generated outputs to the same standard you'd apply in a real submission
- Self-directed and comfortable working independently in an asynchronous environment
Nice to Have
- Prior experience with data annotation, data quality evaluation, or AI output assessment
- Background in pharmacology, oncology, rare disease, or another specialized therapeutic area
- Familiarity with ICH guidelines, GCP standards, or regulatory submission frameworks
- Experience working across multidisciplinary research teams
Why Join Us
- Work directly on frontier AI systems that are reshaping how clinical and biomedical research is conducted
- Influence how AI understands and evaluates real-world clinical evidence — at a scale no individual trial could achieve
- Fully remote and flexible — work when and where it suits you
- Freelance autonomy with the structure of meaningful, high-impact, task-based work
- Collaborate with world-leading AI research labs on problems that matter
- Potential for ongoing work and contract extension as new projects launch
Additional Details
- City
- Chicago
- State
- Illinois
- Country
- US
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