Principal Clinical Scientist
Alignerr · Austin, CO
CONTRACT
Posted Sep 7, 2026
Job Description
Principal Clinical Scientist (AI Training)
About The Role
What if your career-long expertise in clinical trial design and regulatory science could directly shape how AI reasons about medical evidence — influencing the systems that will define the future of biomedical research?
We're looking for a Principal Clinical Scientist to bring senior-level clinical rigor into the development of cutting-edge AI models. You'll work alongside world-leading AI research teams to ensure the clinical data, analyses, and reasoning embedded in frontier AI systems meet the standards expected in real-world regulatory submissions.
This is a fully remote, flexible contract role built for experienced clinical scientists who want to do meaningful work on their own terms.
- Organization: Alignerr
- Type: Hourly Contract
- Location: Remote
- Commitment: 10–40 hours/week
What You'll Do
- Design and critically review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation
- Interpret and audit clinical trial results to ensure accuracy, internal consistency, and alignment with regulatory standards
- Evaluate AI-generated clinical analyses for scientific soundness, methodological integrity, and regulatory relevance
- Provide expert, structured feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes
- Help establish the bar for what rigorous, trustworthy clinical AI looks like in practice
Who You Are
- Senior-level clinical scientist with hands-on experience designing trial protocols for regulatory submission (FDA, EMA, or equivalent)
- Deep expertise interpreting clinical data and navigating the expectations of major regulatory agencies
- Strong grounding in clinical research methodology, biostatistics, translational science, or a related discipline
- Meticulous and structured in how you evaluate evidence — you notice when something doesn't hold up
- Able to communicate complex scientific judgments clearly and concisely in written form
- Comfortable working independently and asynchronously in a remote environment
Nice to Have
- Prior experience with data annotation, data quality frameworks, or AI evaluation workflows
- Background in pharmacovigilance, outcomes research, or health technology assessment
- Familiarity with AI tools or clinical informatics platforms
Why Join Us
- Work directly on frontier AI systems that are reshaping how clinical and biomedical research is understood and conducted
- Influence how AI evaluates, interprets, and communicates real-world clinical evidence at scale
- Fully remote and flexible — work when and where it suits you, with no fixed schedule
- Freelance autonomy with meaningful, intellectually rigorous work on every project
- Collaborate with leading AI research labs and clinical experts from around the world
- Potential for ongoing work and contract extension as new projects launch
About The Role
What if your career-long expertise in clinical trial design and regulatory science could directly shape how AI reasons about medical evidence — influencing the systems that will define the future of biomedical research?
We're looking for a Principal Clinical Scientist to bring senior-level clinical rigor into the development of cutting-edge AI models. You'll work alongside world-leading AI research teams to ensure the clinical data, analyses, and reasoning embedded in frontier AI systems meet the standards expected in real-world regulatory submissions.
This is a fully remote, flexible contract role built for experienced clinical scientists who want to do meaningful work on their own terms.
- Organization: Alignerr
- Type: Hourly Contract
- Location: Remote
- Commitment: 10–40 hours/week
What You'll Do
- Design and critically review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation
- Interpret and audit clinical trial results to ensure accuracy, internal consistency, and alignment with regulatory standards
- Evaluate AI-generated clinical analyses for scientific soundness, methodological integrity, and regulatory relevance
- Provide expert, structured feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes
- Help establish the bar for what rigorous, trustworthy clinical AI looks like in practice
Who You Are
- Senior-level clinical scientist with hands-on experience designing trial protocols for regulatory submission (FDA, EMA, or equivalent)
- Deep expertise interpreting clinical data and navigating the expectations of major regulatory agencies
- Strong grounding in clinical research methodology, biostatistics, translational science, or a related discipline
- Meticulous and structured in how you evaluate evidence — you notice when something doesn't hold up
- Able to communicate complex scientific judgments clearly and concisely in written form
- Comfortable working independently and asynchronously in a remote environment
Nice to Have
- Prior experience with data annotation, data quality frameworks, or AI evaluation workflows
- Background in pharmacovigilance, outcomes research, or health technology assessment
- Familiarity with AI tools or clinical informatics platforms
Why Join Us
- Work directly on frontier AI systems that are reshaping how clinical and biomedical research is understood and conducted
- Influence how AI evaluates, interprets, and communicates real-world clinical evidence at scale
- Fully remote and flexible — work when and where it suits you, with no fixed schedule
- Freelance autonomy with meaningful, intellectually rigorous work on every project
- Collaborate with leading AI research labs and clinical experts from around the world
- Potential for ongoing work and contract extension as new projects launch
Additional Details
- City
- Austin
- State
- Colorado
- Country
- US
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