Postdoc research fellow Full-time

The dos Santos laboratory in the Department of Oncology at St. Jude Children's Research Hospital is seeking a highly motivated postdoctoral research associate to investigate the cellular and molecular mechanisms that regulate mammary gland biology and breast cancer susceptibility. Research in the dos Santos laboratory focuses on how genetic predisposition interacts with systemic and tissue-level factors, including inflammation, infection, pregnancy, aging, and hormonal changes, to influence mammary epithelial cell identity, the tissue microenvironment, and breast cancer initiation.

The successful candidate will lead an independent but highly collaborative project examining mechanisms of breast cancer initiation and progression.

Potential research directions include

• Examining how pregnancy, aging, and hormonal transitions affect mammary tissue organization and tumor risk.
• Investigating the molecular and cellular basis for increased breast cancer risk in Childhood cancer survivors Design, conduct, analyze, and interpret independent research projects.
• Perform molecular, cellular, imaging, and functional assays relevant to mammary gland and cancer biology.
• Present findings at laboratory meetings, institutional seminars, and national or international conferences.
• Prepare manuscripts, fellowship applications, and research proposals.
• Mentor graduate students, research staff, and other junior laboratory members.
• Contribute to a rigorous, collaborative, inclusive, and intellectually engaging laboratory environment. PhD, MD, MD/PhD, or equivalent doctoral degree in cancer biology, molecular biology, cell biology, developmental biology, genetics, immunology, bioengineering, computational biology, or a related discipline.
• Strong record of scientific productivity and evidence of independent research ability.
• Experience with at least one of the following: mouse models, organoid culture, molecular and cellular biology, microscopy, flow cytometry, single-cell genomics, epigenomics, or computational analysis.
• Ability to work independently while contributing effectively to collaborative projects.
• Commitment to rigorous, reproducible, and ethical research. Applicants with complementary expertise in immunology, stromal biology, developmental biology, aging, metabolism, bioengineering, or computational genomics are strongly encouraged to apply.

Research Environment The dos Santos laboratory is located within the Department of Oncology at St. Jude Children's Research Hospital in Memphis, Tennessee. Jude provides an exceptional multidisciplinary research environment with state-of-the-art shared resources in animal modeling, organoid biology, flow cytometry, advanced microscopy, single-cell and spatial genomics, proteomics, computational biology, genome engineering, and biostatistics.

The successful candidate will receive close scientific mentorship and support in developing an independent research identity. Opportunities are available for interdisciplinary collaboration, professional development, conference participation, fellowship applications, manuscript preparation, and career advancement in academic, clinical, biotechnology, or pharmaceutical research.

Application Instructions A cover letter describing their research experience, scientific interests, and reasons for joining the dos Santos laboratory.

• A brief summary of previous research accomplishments and future research interests.
• Applications should be sent to Dr. org with the subject line "Postdoctoral Application - [Applicant's Name]." Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities.