Oligonucleotide Scientist II

Working Model: Fully on-site, South San Francisco, CA

Working Days: Monday to Friday

Working Hours: Standard 8 hour shift

Interview Format: One Round (30 minutes) - Local candidates should join the interviews on site, candidates outside of the immediate area may join virtually.

The Position:

We are seeking a creative, self-motivated, collaborative Contractor/Scientist-II to join the

Nucleic Acid Design and Discovery (NADD) team within ProteinSciences (PS) department at

Genentech. We are looking for a candidate with experience in oligonucleotide discovery and

synthesis to support our new oligonucleotide therapeutics discovery group. Experience in

delivery of oligonucleotide therapeutics, large molecule drug discovery, would be preferred. The

successful candidate will join an interdisciplinary chemistry team working in RNAi biology

research and will contribute positively to its developing culture.

Key Responsibilities:

. The candidate will work in an oligonucleotide therapeutic drug discovery research lab

and interface across different therapeutic areas, including neuroscience, immunology

and oncology, to help build a comprehensive therapeutic discovery strategy.

. Good understanding and also troubleshooting experience in oligonucleotide synthesis,

impurity profiling is a plus.

. Collaborate with other scientists to maintain common lab equipment such as oligo

synthesizers, HPLC and desalting units.

. Perform literature reviews, propose, and execute nucleic acid chemistry plans,

coordinate chemistry and biology data to support oligonucleotide compound

progression.

. Establish methods for scaled-up synthesis of lead molecules and coordinate material

delivery for preclinical studies.

. Maintaining a high level of productivity in the laboratory setting to meet the timelines

for in vitro and in vivo studies.

Requirements:

. The candidate must have hands-on experience in oligonucleotide synthesis using

automated oligo synthesizers, Client nucleic acid chemistry, oligonucleotide purification

and characterization using HPLC and mass spectrometry.

. The qualified individual will possess a BS/MS in Organic Chemistry or related discipline.

. The pharmaceutical or biotechnology industry experience in research and development

of RNAi therapeutics is preferred.

. A good understanding of nucleic acid therapeutic modalities, modification chemistries,

sequence selection, and mechanism of action is preferred. Relevant experience in

oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or

bio-conjugation is desirable.

. Good communication and interpersonal skills are essential and will be evaluated during

the interview process.

. The ideal candidate should be highly motivated and have strong problem-solving,

analytical, communication and organizational skills.





Skills:

Analysis Skills, Biology, Biotech and Pharmaceutical, Chemistry, Communication Skills, Drug Discovery, Equipment Maintenance/Repair, High Performance Liquid Chromatography (HPLC), Identify Issues, Immunology, Interpersonal Skills, Laboratory Equipment, Neuroscience, Nucleic Acid, Oncology, Organizational Skills, Pre-Clinical Trials, Research & Development (R&D), Research Laboratory, Team Player, Time Management



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Tailored Management



CONNECTING TOP TALENT WITH TOP-TIER OPPORTUNITIES
Tailored Management is a global staffing firm that specializes in partnering with large organizations that run their contingent labor program in a VMS/MSP environment. We have the unique capacity to support programs across all scopes and geographic locations from a single headquarters, successfully elevating program performance across the board and minimizing costs, miscommunication and delivery times. But what do we really do? We bring together the best talent with the greatest opportunities.





Company Size:

1,000 to 1,499 employees



Industry:

Staffing/Employment Agencies



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Website:

https://www.tailoredmanagement.com/