Oligonucleotide Scientist II

Working Model: Fully on-site, South San Francisco, CA



Working Days: Monday to Friday



Working Hours: Standard 8 hour shift



Interview Format: One Round (30 minutes) - Local candidates should join the interviews on site, candidates outside of the immediate area may join virtually.



The Position:



We are seeking a creative, self-motivated, collaborative Contractor/Scientist-II to join the



Nucleic Acid Design and Discovery (NADD) team within ProteinSciences (PS) department at




- We are looking for a candidate with experience in oligonucleotide discovery and





synthesis to support our new oligonucleotide therapeutics discovery group. Experience in



delivery of oligonucleotide therapeutics, large molecule drug discovery, would be preferred. The



successful candidate will join an interdisciplinary chemistry team working in RNAi biology



research and will contribute positively to its developing culture.



Key Responsibilities:




- The candidate will work in an oligonucleotide therapeutic drug discovery research lab





and interface across different therapeutic areas, including neuroscience, immunology



and oncology, to help build a comprehensive therapeutic discovery strategy.




- Good understanding and also troubleshooting experience in oligonucleotide synthesis,





impurity profiling is a plus.




- Collaborate with other scientists to maintain common lab equipment such as oligo





synthesizers, HPLC and desalting units.




- Perform literature reviews, propose, and execute nucleic acid chemistry plans,





coordinate chemistry and biology data to support oligonucleotide compound



progression.




- Establish methods for scaled-up synthesis of lead molecules and coordinate material





delivery for preclinical studies.




- Maintaining a high level of productivity in the laboratory setting to meet the timelines





for in vitro and in vivo studies.



Requirements:




- The candidate must have hands-on experience in oligonucleotide synthesis using





automated oligo synthesizers, Client nucleic acid chemistry, oligonucleotide purification



and characterization using HPLC and mass spectrometry.




- The qualified individual will possess a BS/MS in Organic Chemistry or related discipline.

- The pharmaceutical or biotechnology industry experience in research and development





of RNAi therapeutics is preferred.




- A good understanding of nucleic acid therapeutic modalities, modification chemistries,





sequence selection, and mechanism of action is preferred. Relevant experience in



oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or



bio-conjugation is desirable.




- Good communication and interpersonal skills are essential and will be evaluated during





the interview process.




- The ideal candidate should be highly motivated and have strong problem-solving,





analytical, communication and organizational skills.