Manager/Associate Director - Predictive Sciences, Asia Translational Medicine

We are seeking a highly motivated translational scientist to join the Predictive Sciences group within Asia Translational Medicine (ATM), where quantitative modeling, clinical pharmacology, biomarkers, and translational data science are integrated to enable model-informed research and development. This role offers a unique opportunity to shape global clinical development by leveraging Asia's rapidly evolving biomedical innovation ecosystem, diverse patient populations, and growing translational research capabilities to generate actionable insights with enterprise-wide impact. In this role, you will partner with regional and global, multidisciplinary clinical and translational teams to develop and apply cutting-edge quantitative approaches that inform clinical development strategies and deepen our understanding of causal disease biology and therapeutic response.

Working across multiple therapeutic areas and advanced therapeutic modalities - including therapeutic proteins, antibodies, and nucleic acids (particularly, siRNA and antisense oligonucleotides) - you will integrate mechanistic modeling, biomarkers, translational -omics, and clinical trial data to enable model-informed drug development. You will also help advance state-of-art predictive modeling methodologies and computational capabilities that strengthen quantitative translational science across the portfolio.

Key responsibilities include:

• Serve as the Predictive Sciences representative on multidisciplinary translational medicine teams, developing and applying quantitative strategies that contribute to biomarker strategy and inform clinical development and model-informed decision making.
• Develop and apply mechanistic modeling approaches - including PK/PD, PBPK/PD, QSP, and AI/ML-enabled analytics - to integrate clinical and translational data, characterize human pharmacology (including ethnopharmacology), evaluate alternative trial designs,