At AstraZeneca we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We are focused on leading a revolution in oncology to redefine cancer care and address the unmet needs of patients around the world. We are following the science to understand cancer and all its complexities so that we can discover, develop and deliver life-changing treatments and increase the potential for cure. The Oncology business is the fastest growing team within AstraZeneca and across the industry. Through our relentless quest for innovation, we have created one of the most diverse portfolios and pipelines in the industry. You will be among inspiring oncology industry leaders who will keep you engaged and empower you to be the best. At AstraZeneca, our franchise teams are pivotal in driving launch and commercial effectiveness, setting direction to shape the cancer care landscape and empower care teams. The Global Commercial Director (Sr Director level) will be a key member of the Breast Cancer Franchise, and will be integral to our collective efforts towards transforming care for cancer patients globally. This strategic role, reporting into the Global Commercial Head, will be accountable for shaping and delivering the global strategy for several indications driving significant growth across regions. The Global Commercial Director will closely partner with key global country and regional leads based in the US, Europe, Asia as well as wide range of headquarter functions. This position is based in Gaithersburg, MD (USA) and requires three days a week onsite presence. Typical Accountabilities | Job Responsibilities Lead global strategy Lead the creation, execution and continuous refinement of the commercial brand strategy for key indications in HER2+ metastatic breast cancer, ensuring robust lifecycle management from prelaunch through postlaunch. Achieve clear differentiation and competitive positioning vs emerging and established players Own commercial leadership Own global commercial leadership of a critical launch for the brand, ensuring sustained performance and delivery against strategic and financial objectives. Act as indication lead in senior forums, communicating commercial performance, financial outlooks and investment trade-offs to senior executives and governance committees. Deliver launch excellence As a key member of the Integrated Brand Teams, partner with Regional and Country teams to set clear priorities, drive accountability and ensure coordinated delivery across functions and deliver launch excellence. Deliver marketing strategies that set up successful launches and maintain strong postlaunch momentum. Partner across functions and markets Collaborate with global cross functional teams including Medical Affairs, Insights and Analytics, and Market Access to deliver the global ambition and ensure alignment Engage regional and key market stakeholders to drive launch readiness, build capabilities and ensure effective deployment of global and local budgets Partner effectively with cross-functional Alliance colleagues to co-develop strategy and launch plans Drive performance and business impact Lead all aspects of postlaunch performance by monitoring uptake, access and executional efficiency, initiating data-driven course corrections and reallocating resources where needed Hold global budget accountability for key indications, including development of the annual operating plan, budget phasing, investment prioritisation. Maximize value throughout the lifecycle Maximize value across pre-launch, launch and in-line phases, across regions Represent and articulate the commercial and marketing strategic vision for key indications within the Global Product Team (GPT), influencing critical decisions and trade-offs. Education, Qualifications, Skills and Experience Over 10 years of experience in pharmaceutical development and commercialization, including at least 5 years in marketing, strategy, or life sciences consulting. Strong Oncology background, having worked in multiple commercial roles for a large/mid-sized pharmaceutical company to drive launch and in-line performance Proven track record in global brand strategy and launch execution Strong strategic thinking, judgment, and influencing skills to lead across regions and markets with clear financial accountability Robust business acumen (forecasting, insights, competition) and problem solving skills Strong experience in pre-launch and in-line brand management Demonstrated ability to lead in a matrix environment and influence without authority Experience working with cross-functional teams (Medical, Access, Insights, etc.) Excellent communication and stakeholder management skills Desirable MBA in relevant field Sales/Customer-facing experience Management experience Successfully launched brands at a global level Experience working in Breast Cancer Experience working in a commercial alliance/partnership environment The annual base pay for this position ranges from 231,988.80 - 347,983.20 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. Date Posted 25-Jun-2026 Closing Date 28-Jun-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca 是一家出色的全球性、创新型生物制药公司。公司以科技为本。通过我们的核心治疗领域，竭诚满足患者的需求缺口。同时大胆创新，积极探索未知领域。全球所有工厂的研发团队群策群力，积极致力于将伟大的构想转化成改变人类生活的药品 – 加强产品组合优势，充分发挥药品开发各个阶段的渠道潜能。 这是一支走在科技前沿的队伍，在他们的努力下，昨日之不可能将发展成明日之常态。如果您与我们具有共同的目标和热情，欢迎加入我们，与我们一同为改变患者的生活而努力。同样，我们也将为您提供更广阔的发展空间。 Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.