Position: Drug hunters (chemists) or toxicologists
Type: Hourly contract
Compensation: $70-$100 per hour
Location: Remote
Commitment: 10–40 hours/week
Role Responsibilities
Review and annotate datasets related to drug discovery, pharmacology, and safety biology
Interpret experimental outputs from target biology studies, biochemical assays, cellular models, and safety screens
Analyze relationships between compound structure, potency, selectivity, exposure, and toxicity signals
Identify mechanistic explanations behind efficacy or toxicity findings across discovery experiments
Distinguish meaningful biological signal from experimental artifacts, assay interference, or model limitations
Audit annotated datasets for biological, pharmacological, and safety accuracy
Validate structure–activity relationships, target engagement logic, and pharmacokinetic interpretations
Evaluate AI-generated reasoning on drug mechanism, toxicity risk, and safety margins
Ensure correct interpretation of dose-response relationships, exposure margins, and translational relevance
Contribute to annotation guidelines for drug discovery workflows, SAR, pharmacokinetics, toxicity mechanisms, and translational biology
Provide expertise on balancing potency, selectivity, safety, and developability
Advise on classification of toxicity findings, safety signals, and risk assessment frameworks
Review AI-generated reasoning on drug mechanism, target biology, toxicity, and pharmacokinetics
Assess whether conclusions logically follow from experimental evidence and biological context
Provide structured feedback to improve scientific rigor and reasoning in model outputs
Contribute to scientific standards documentation and training materials
Help define gold‑standard examples of drug discovery reasoning and toxicity interpretation
Support calibration workflows across pharmacology, toxicology, and translational biology
Requirements
Advanced degree such as PhD, PharmD, DVM, MD, or MS with significant industry experience in medicinal chemistry, pharmacology, toxicology, chemical biology, molecular biology, pharmaceutical sciences, or biochemistry
Hands‑on experience in drug discovery or safety assessment including target validation through lead optimization
Experience in structure–activity relationship analysis
Experience in pharmacokinetics and ADME interpretation
Experience in toxicology and safety pharmacology studies
Experience interpreting in vitro and in vivo experimental data
Strong expertise in target biology and mechanism‑of‑action reasoning
Understanding of dose‑response relationships and exposure margins
Ability to interpret translational relevance between preclinical and clinical findings
Knowledge of toxicity mechanisms such as liver toxicity, cardiovascular liabilities, genotoxicity, or reproductive toxicity
Ability to evaluate safety findings for risk and program impact
Experience reviewing primary experimental data and study reports
Exceptional attention to scientific accuracy and mechanistic reasoning
Experience in pharmaceutical or biotechnology drug discovery teams
Background in lead optimization, translational biology, or nonclinical safety
Familiarity with DMPK workflows, safety biomarkers, and regulatory toxicology considerations
Experience contributing to cross‑functional discovery teams
Exposure to AI or ML tools applied to biomedical research

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