About the role, the Director, Operational Excellence (OE) leads the network-wide OE agenda for AstraZeneca's autologous Cell Therapy. You will establish basic conditions and eliminate waste across the vein-to-vein value stream. You will operate in a matrix with site-based OE Leads. It sets strategy, governs the improvement portfolio, and delivers measurable outcomes in cost, productivity, service, quality, safety, and compliance. Additionally, it builds sustainable capabilities for scale. This role offers flexibility to be based in Rockville, MD or Tarzana, CA. You Will: Lead end-to-end value stream mapping. Deploy Hoshin/strategy deployment to translate targets, such as COGM, capacity, and service, into a governed portfolio. This portfolio have clear owners, milestones, risks, and benefits. Additionally, create standardized COGM/productivity dashboards and benefit tracking with Finance. Lead programs (cycle time, labor models, MES/EBR enablement, yield, changeovers/scheduling, deviation reduction, automation/technology insertion). Apply the AZ Lean Model (A3, VSM, standard work, daily/tier management, leader standard work, adapted SMED). Facilitate development of business processes for training, batch execution, deviations, and patient/lot scheduling and logistics. Lead Kaizen events; scale best practices across the Cell Therapy Development and Operations. Define basic conditions for Cell Therapy Manufacturing Sites and build capability at all levels; coach leaders and value stream owners Partner with Supply Chain to vein-to-vein flow, slotting, and cold-chain logistics, safeguarding Chain of Identity/Chain of Custody. Ensure improvements uphold safety, patient focus, and cGMP for ATMPs (including GAMP and data integrity). Partner with Quality to reduce human error and increase First Pass Success and right-first-time performance. Align senior leaders on priorities and resources; communicate impact through governance forums. You Have : Bachelor's in engineering/Life Sciences or related; advanced degree preferred. 10+ years in GMP manufacturing; 5+ years leading programs. Recognized Lean Six Sigma Black Belt or equivalent depth of OE expertise. COGM/productivity improvements using lean, digital, and analytics. Expertise in value stream management and lean (Hoshin, A3, VSM, standard work, tier/visual management, leader standard work); Genba execution. Command of cGMP, data integrity, and GAMP; experience with MES/EBR/LIMS and other digital systems Track record in cross-site program leadership, portfolio governance, and benefits realization with Finance. Demonstrated experience in Influence without authority, change leadership, and process/project/risk/Analytical skills. The annual base pay for this position ranges from $148 to $222K. Our positions offer eligibility for multiple incentives an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans. Date Posted 12-Jun-2026 Closing Date 09-Jul-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca är ett globalt, innovationsdrivet bioläkemedelsföretag som inspireras av vetenskapens möjligheter. Vår drivkraft är att uppfylla patientens behov inom våra terapeutiska kärnområden. Med vårt djärva tankesätt arbetar vi proaktivt med att genomföra upptäckter bortom fantasins gränser. På olika platser runtom i världen sammanför vi team som präglas av samarbetsanda för att omvandla fantastiska idéer till läkemedel som kan förändra liv. Vi förstärker vår produktportfölj och drar nytta av potentialen med en processlinje i alla stadier av läkemedelsutvecklingen. Du blir en del av ett team som ständigt utmanar vetenskapens gränser och bidrar till att det som var omöjligt igår ses som morgondagens standard. Delar du vårt fokus och vår passion? I så fall ska du börja arbeta hos oss och hjälpa oss göra skillnad för patienter. I gengäld hjälper vi dig att utvecklas mer än du trodde var möjligt. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.