Chromatography / Separation Scientist

Job description
Open roles across AI research, scientific engineering and flavor science. If none of them is yours, the talent pool is one tab away.

### Join us as a hands-on expert in chromatography, sample preparation, and analytical method development.

### About Noah's Farm

Noah's Farm is an **AI-driven flavor discovery and molecular design company** headquartered in Singapore, with operations in Korea and the United States. We combine machine learning, computational chemistry, biology, analytical science, and sensory research to develop flavor formulations and discover new flavor molecules.

We have **raised $2.8 million in pre-seed funding and secured commitments for $10 million in seed funding.** This funding supports the advancement of our core technology, expansion of our experimental infrastructure, and growth of our research team.

We have also **successfully translated AI-designed flavor formulas into physical formulations and identified new candidate molecules** , establishing a technical foundation that connects computational design with laboratory experimentation. We are now building on these achievements to create a reproducible and scalable R\&D process.

**Strong chromatography expertise is essential to our laboratory.** We are looking for a scientist who can independently operate instruments, develop effective separation methods, solve sample-preparation challenges, and produce reliable qualitative and quantitative results.

### **Job Description**

The Chromatography / Separation Scientist is a **hands-on analytical scientist focused on chromatography, sample preparation, method development, and instrument troubleshooting.**

We are looking for someone who can independently operate chromatography and associated detection systems, select suitable separation conditions, prepare complex samples, and obtain reproducible qualitative and quantitative results. You will develop methods from initial feasibility testing through validation and routine use, and resolve practical problems such as poor separation, peak tailing, co-elution, low recovery, carryover, and matrix effects.

The core of this role is **doing chromatography well** : understanding why an analytical method works, recognizing when a result is unreliable, and knowing how to improve the method or resolve the problem.

### **Key Responsibilities**

**Operate chromatography instruments and perform analysis**

Independently operate **LC-QTOF-DAD and GC-TQ-FID** for qualitative and quantitative analysis of non-volatile and volatile compounds.

Select appropriate detection modes and acquisition conditions, prepare analytical sequences with blanks, standards, and controls, and verify instrument readiness and system suitability.

**Develop and optimize separation methods**

For LC, optimize columns, mobile phases, gradients, flow rates, injection volumes, and temperatures, and establish QTOF and DAD acquisition conditions.

For GC, optimize columns, carrier-gas flow, oven temperature programs, and injection conditions, and establish TQ and FID acquisition conditions.

Improve resolution, peak shape, sensitivity, and run-to-run reproducibility for the sample and analytical objective.

**Develop and troubleshoot sample preparation**

Establish extraction, dilution, concentration, derivatization, filtration, and cleanup procedures suitable for complex samples.

Investigate recovery, analyte loss, degradation, adsorption, contamination, and matrix effects through controlled experiments.

**Validate methods and interpret analytical results**

Establish calibration and internal-standard strategies and assess selectivity, linearity, LOD/LOQ, accuracy, precision, recovery, and robustness as appropriate.

Interpret chromatograms and mass spectra, perform peak identification and quantification, and recognize analytical artifacts and limitations.

**Troubleshoot instruments and maintain reliable laboratory operation**

Diagnose poor separation, retention-time drift, peak tailing, carryover, background contamination, and instrument-performance problems.

Perform routine maintenance and system-suitability checks, and document methods, analytical records, and corrective actions in clear SOPs and laboratory records.

### **Requirements**

M.S., Ph.D., or equivalent industry experience in analytical chemistry, separation science, metabolomics, or a related field

Hands-on experience operating LC- and GC-based analytical instruments, developing analytical methods, and troubleshooting instrument and method-performance issues

Hands on experience on operating and troubleshooting mass spectrometry instruments.

Understanding of mass spectrometry and DAD/FID detection, with the ability to select fit-for-purpose acquisition conditions and interpret analytical results

Demonstrated ability to develop analytical assays from initial method design through validation and routine operation

Strong knowledge of sample preparation, extraction, calibration, internal standards, matrix effects, LOD/LOQ, precision, accuracy, recovery, and instrument quality control

Experience with small-molecule assays, targeted metabolomics, volatile compounds, or complex food and biological samples

Ability to create clear SOPs, maintain data quality, and work independently in an early-stage laboratory environment

### **Preferred Qualifications**

**Complex-matrix analysis:** Experience analyzing volatile or non-volatile compounds in foods, flavors, natural products, or biological samples

**Advanced sample preparation and separation:** Hands-on experience with headspace, SPME, SPE, LLE, QuEChERS, derivatization, SAFE, or multidimensional chromatography

**Compound identification and quantitative analysis:** Experience using QTOF accurate-mass and MS/MS data for compound identification, GC-TQ MRM methods for quantitative analysis, or DAD/FID-based quantification

**Relevant instrument experience and analytical quality:** Direct experience operating LC-QTOF-DAD or GC-TQ-FID, particularly in troubleshooting, maintenance, instrument qualification, method transfer, or work under GLP, GMP, ISO 17025, or related quality systems

Ready when you are. The application takes about ten minutes.
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