Cell Therapy Infusion Registered Nurse (RN)
American Research Corporation · San Antonio, TX
Job Description
About Us
American Research Corporation (ARC) is a clinical research site in San Antonio, Texas, led by hepatologist and Principal Investigator Dr. Eric Lawitz. Our team conducts clinical trials across liver disease and immune-mediated conditions. This role supports an investigational Treg cell therapy program in autoimmune liver disease, where the therapeutic goal is modulation of the immune response rather than cytotoxic effect.
General Summary
American Research Corporation (ARC) is seeking an experienced infusion nurse to administer investigational regulatory T cell (Treg) therapy to patients enrolled in clinical research studies. This is not a standard infusion role. You will be handling a single-patient, one-of-one cellular product under strict chain-of-identity requirements, administering it under protocol-defined conditions, and monitoring for the specific reaction profile associated with cell therapy.
If you have cellular therapy, apheresis, transplant, or biologic infusion experience and want to work at the front edge of immune tolerance research on a schedule you control, we would like to talk with you.
What Makes This Role Different • A one-of-one product. The investigational product is manufactured for a single identified patient, with no replacement dose. Chain of identity and chain of custody verification, including label verification and two-person bedside confirmation, are central to the role.
• A defined delivery window. Product is supplied with a limited window for infusion following release, whether administered fresh or thawed immediately prior to administration.
Infusion timing is driven by product release, not clinic convenience.
• Protocol-specific administration mechanics. Cellular products are not administered like standard biologics.
Administration follows the protocol-defined method and SOP. • A Treg-specific safety profile. Unlike CAR-T oncology products, Treg therapy does not carry routine cytokine release syndrome or neurotoxicity risk. Monitoring instead focuses on acute infusion and hypersensitivity reactions in the first 24 hours, effects related to product preparation, infection surveillance, and signs of rejection or disease flare.
Essential Job Functions Product Receipt and Handling
• Receive, verify, and document the investigational cellular product against protocol requirements, including ISBT 128 labeling, product identity, integrity, and expiration or infuse-by time.
• Maintain chain of identity and chain of custody documentation from receipt through administration and final disposition.
• Coordinate with the cell therapy lab / sponsor / courier on release timing, cold chain, and any temperature excursion or delay.
• Complete two-person verification of patient and product identity at the bedside prior to infusion.
Infusion Administration • Administer cell therapy and other investigational biologic infusions per study protocol, sponsor requirements, and physician orders.
• Establish and maintain IV access; calculate and monitor infusion rates; operate infusion pumps and related equipment.
• Administer protocol-specified premedication, observing protocol restrictions on agents that may affect cell viability or function.
• Administer the product by the protocol-defined method and rate, using approved tubing and avoiding prohibited filters, pumps, or co-infused fluids.
Patient Monitoring and Safety • Monitor patients throughout the infusion and protocol-defined observation period for adverse events and infusion-related reactions; recognize and respond to emergent complications per protocol and rescue procedures.
• Recognize and respond to acute infusion and hypersensitivity reactions; initiate rescue medications and escalation per protocol.
• Escalate to the Principal Investigator or sub-investigator and activate emergency response per site procedure.
• Educate patients and caregivers on the infusion procedure, expected effects, and post-infusion care instructions.
Documentation and Study Compliance • Accurately document vital signs; infusion start/stop times, product administration, and adverse events in source documents.
• Maintain compliance with Good Clinical Practice (GCP), IRB requirements, and sponsor-specific training for each assigned study.
• Report adverse events and protocol deviations promptly to the Principal Investigator and clinical research team.
• Coordinate infusion visit scheduling with the clinical research coordinator and study team to ensure protocol-required windows are met.
• Maintain infusion suite supplies, equipment readiness, and emergency response materials.
• Perform other duties as assigned.
Organizational Relationships • The Cell Therapy Infusion Nurse is engaged by American Research Corporation (ARC) on a PRN basis and is accountable to the Human Resources Department for administrative matters.
• The Cell Therapy Infusion Nurse works under the direct supervision of the Principal Investigator for all clinical and protocol-related matters.
• The Cell Therapy Infusion Nurse is responsible for maintaining all required licenses and certifications as required by law.
Required Qualifications • Active, unencumbered Registered Nurse (RN) license in the State of Texas.
• Current BLS certification.
• Current ACLS certification
• Minimum 1-2 years of infusion nursing experience in cellular therapy, HSCT, apheresis, solid organ transplant, oncology infusion, or biologic infusion.
• Demonstrated competency in peripheral and central venous access, including CVAD management.
• Experience recognizing and managing infusion reactions, hypersensitivity, and anaphylaxis.
• Accurate documentation in electronic systems and source documents.
Preferred Qualifications • Prior experience administering cellular therapy products – Treg, CAR-T, TIL, NK cell, HPC, or MSC.
• Experience with cryopreserved product thaw and DMSO reaction management.
• Apheresis or leukapheresis experience.
• Solid organ transplant or immune tolerance experience; familiarity with immunosuppression monitoring.
• ONS/ONCC Chemotherapy Immunotherapy Certificate, OCN, TCTCN (formerly BMTCN), or CRNI.
• Familiarity with FACT standards, USP hazardous drug handling, and ISBT 128 labeling.
• Prior clinical research or GCP experience is not required, as we provide full protocol training.
• Bilingual English/Spanish.
Why Join Us • Genuine PRN flexibility: a defined, predictable number of infusion days rather than open-ended on-call.
• Specialized experience that transfers: hands-on cellular therapy product handling and administration is among the most portable skill sets in nursing today.
• Real depth, not volume: a low patient ratio and a long observation period mean you practice at the top of your assessment skills.
• Direct investigator access: you work alongside the Principal Investigator and study team, not several layers removed.
• Meaningful science: immune tolerance research aimed at changing how [indication] is treated.
Benefits: • Flexible schedule
Work Location: In person
American Research Corporation (ARC) is a clinical research site in San Antonio, Texas, led by hepatologist and Principal Investigator Dr. Eric Lawitz. Our team conducts clinical trials across liver disease and immune-mediated conditions. This role supports an investigational Treg cell therapy program in autoimmune liver disease, where the therapeutic goal is modulation of the immune response rather than cytotoxic effect.
General Summary
American Research Corporation (ARC) is seeking an experienced infusion nurse to administer investigational regulatory T cell (Treg) therapy to patients enrolled in clinical research studies. This is not a standard infusion role. You will be handling a single-patient, one-of-one cellular product under strict chain-of-identity requirements, administering it under protocol-defined conditions, and monitoring for the specific reaction profile associated with cell therapy.
If you have cellular therapy, apheresis, transplant, or biologic infusion experience and want to work at the front edge of immune tolerance research on a schedule you control, we would like to talk with you.
What Makes This Role Different • A one-of-one product. The investigational product is manufactured for a single identified patient, with no replacement dose. Chain of identity and chain of custody verification, including label verification and two-person bedside confirmation, are central to the role.
• A defined delivery window. Product is supplied with a limited window for infusion following release, whether administered fresh or thawed immediately prior to administration.
Infusion timing is driven by product release, not clinic convenience.
• Protocol-specific administration mechanics. Cellular products are not administered like standard biologics.
Administration follows the protocol-defined method and SOP. • A Treg-specific safety profile. Unlike CAR-T oncology products, Treg therapy does not carry routine cytokine release syndrome or neurotoxicity risk. Monitoring instead focuses on acute infusion and hypersensitivity reactions in the first 24 hours, effects related to product preparation, infection surveillance, and signs of rejection or disease flare.
Essential Job Functions Product Receipt and Handling
• Receive, verify, and document the investigational cellular product against protocol requirements, including ISBT 128 labeling, product identity, integrity, and expiration or infuse-by time.
• Maintain chain of identity and chain of custody documentation from receipt through administration and final disposition.
• Coordinate with the cell therapy lab / sponsor / courier on release timing, cold chain, and any temperature excursion or delay.
• Complete two-person verification of patient and product identity at the bedside prior to infusion.
Infusion Administration • Administer cell therapy and other investigational biologic infusions per study protocol, sponsor requirements, and physician orders.
• Establish and maintain IV access; calculate and monitor infusion rates; operate infusion pumps and related equipment.
• Administer protocol-specified premedication, observing protocol restrictions on agents that may affect cell viability or function.
• Administer the product by the protocol-defined method and rate, using approved tubing and avoiding prohibited filters, pumps, or co-infused fluids.
Patient Monitoring and Safety • Monitor patients throughout the infusion and protocol-defined observation period for adverse events and infusion-related reactions; recognize and respond to emergent complications per protocol and rescue procedures.
• Recognize and respond to acute infusion and hypersensitivity reactions; initiate rescue medications and escalation per protocol.
• Escalate to the Principal Investigator or sub-investigator and activate emergency response per site procedure.
• Educate patients and caregivers on the infusion procedure, expected effects, and post-infusion care instructions.
Documentation and Study Compliance • Accurately document vital signs; infusion start/stop times, product administration, and adverse events in source documents.
• Maintain compliance with Good Clinical Practice (GCP), IRB requirements, and sponsor-specific training for each assigned study.
• Report adverse events and protocol deviations promptly to the Principal Investigator and clinical research team.
• Coordinate infusion visit scheduling with the clinical research coordinator and study team to ensure protocol-required windows are met.
• Maintain infusion suite supplies, equipment readiness, and emergency response materials.
• Perform other duties as assigned.
Organizational Relationships • The Cell Therapy Infusion Nurse is engaged by American Research Corporation (ARC) on a PRN basis and is accountable to the Human Resources Department for administrative matters.
• The Cell Therapy Infusion Nurse works under the direct supervision of the Principal Investigator for all clinical and protocol-related matters.
• The Cell Therapy Infusion Nurse is responsible for maintaining all required licenses and certifications as required by law.
Required Qualifications • Active, unencumbered Registered Nurse (RN) license in the State of Texas.
• Current BLS certification.
• Current ACLS certification
• Minimum 1-2 years of infusion nursing experience in cellular therapy, HSCT, apheresis, solid organ transplant, oncology infusion, or biologic infusion.
• Demonstrated competency in peripheral and central venous access, including CVAD management.
• Experience recognizing and managing infusion reactions, hypersensitivity, and anaphylaxis.
• Accurate documentation in electronic systems and source documents.
Preferred Qualifications • Prior experience administering cellular therapy products – Treg, CAR-T, TIL, NK cell, HPC, or MSC.
• Experience with cryopreserved product thaw and DMSO reaction management.
• Apheresis or leukapheresis experience.
• Solid organ transplant or immune tolerance experience; familiarity with immunosuppression monitoring.
• ONS/ONCC Chemotherapy Immunotherapy Certificate, OCN, TCTCN (formerly BMTCN), or CRNI.
• Familiarity with FACT standards, USP hazardous drug handling, and ISBT 128 labeling.
• Prior clinical research or GCP experience is not required, as we provide full protocol training.
• Bilingual English/Spanish.
Why Join Us • Genuine PRN flexibility: a defined, predictable number of infusion days rather than open-ended on-call.
• Specialized experience that transfers: hands-on cellular therapy product handling and administration is among the most portable skill sets in nursing today.
• Real depth, not volume: a low patient ratio and a long observation period mean you practice at the top of your assessment skills.
• Direct investigator access: you work alongside the Principal Investigator and study team, not several layers removed.
• Meaningful science: immune tolerance research aimed at changing how [indication] is treated.
Benefits: • Flexible schedule
Work Location: In person
Additional Details
- City
- San Antonio
- State
- Texas
- Country
- US
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