Associate Research Scientist
Integrated Resources, Inc · Lexington, MA
CONTRACT
Posted Sep 9, 2026
Job Description
Title: Associate Research Scientist Contractor, RNAi Formulations
Location: Lexington - MA
Duration: 1 year
Reporting Expectations: Onsite; Monday to Friday, 8:00 AM to 5:00 PM
Top 3 skills:
1. Lab experience in formulation of oligonucleoProducts or antibodies for subcutaneous injection
2. Hands on analytical characterization of oligonucleoProducts or antibodies/protein
3. Experience with developability assessments, including evaluation of parameters like maximum solubility, viscosity, osmolality, limited chemical, and physical stability
Job description:
- The Associate Research Scientist Contractor, RNAi Formulations, will be based within Non-Viral Delivery (NVD) in Research & Early Development. This is a laboratory-based role focused on hands-on RNAi formulation development, biophysical and analytical characterization, and support of oligonucleoProduct delivery activities for injectable therapeutics.
Relationships:
- Reports to the US Team Manager for Nucleic Acid Delivery, Formulations and Bioanalysis. Interacts closely with peers and cross-functional partners specializing in non-viral delivery, formulation development, oligonucleoProducts chemistry, stability assays, PK, bioanalysis, Client, and external collaborators.
Essential Functions:
- Support the development and characterization of preclinical RNAi and oligonucleoProducts formulations across portfolio and platform projects.
- Execute hands-on formulation preparation, biophysical characterization, analytical testing, and data analysis to support formulation selection and developability assessments.
- Establish and run screening assays for oligonucleoProducts in early discovery, including formulation performance, solubility, viscosity, osmolality, degradation, , and stability assessments.
- Contribute to high-throughput and design-of-experiments approaches for formulation optimization, where applicable.
- Support long-term storage and stability evaluations for RNAi conjugates and oligonucleoProducts formulations.
- Maintain accurate experimental documentation and communicate findings through written summaries, reports, and internal presentations.
- Collaborate with internal stakeholders and external partners to support project deliverables and timelines.
- Identify technical gaps, propose practical solutions, and contribute to continuous improvement of formulation and characterization workflows.
- Thrive in a multidisciplinary, fast-paced research environment with competing priorities and tight deadlines.
Qualifications And Skills:
- MS with approximately 3 years of relevant experience, or PhD with 1-3 years of relevant experience in pharmaceutical sciences, formulation sciences, chemical engineering, biophysics, analytical chemistry, oligonucleoProducts delivery, or a related discipline.
- Hands-on experience with oligonucleoProducts or antibodies/proteins formulation and characterization is strongly preferred.
- Experience developing or running analytical methods for solubility, viscosity, osmolality, aggregation, , stability, or other developability assessments for complex oligonucleoProducts or antibody/protein formulations.
- Familiarity with automation, high-throughput screening, and DoE-based formulation optimization is an advantage.
- Strong experimental planning, documentation, data analysis, and problem-solving skills.
- Awareness of external trends and advances in RNA delivery, oligonucleoProducts therapeutics, and clinical translation is a plus.
- A track record of scientific contributions, publications, or conference presentations in relevant areas is a plus.
Location: Lexington - MA
Duration: 1 year
Reporting Expectations: Onsite; Monday to Friday, 8:00 AM to 5:00 PM
Top 3 skills:
1. Lab experience in formulation of oligonucleoProducts or antibodies for subcutaneous injection
2. Hands on analytical characterization of oligonucleoProducts or antibodies/protein
3. Experience with developability assessments, including evaluation of parameters like maximum solubility, viscosity, osmolality, limited chemical, and physical stability
Job description:
- The Associate Research Scientist Contractor, RNAi Formulations, will be based within Non-Viral Delivery (NVD) in Research & Early Development. This is a laboratory-based role focused on hands-on RNAi formulation development, biophysical and analytical characterization, and support of oligonucleoProduct delivery activities for injectable therapeutics.
Relationships:
- Reports to the US Team Manager for Nucleic Acid Delivery, Formulations and Bioanalysis. Interacts closely with peers and cross-functional partners specializing in non-viral delivery, formulation development, oligonucleoProducts chemistry, stability assays, PK, bioanalysis, Client, and external collaborators.
Essential Functions:
- Support the development and characterization of preclinical RNAi and oligonucleoProducts formulations across portfolio and platform projects.
- Execute hands-on formulation preparation, biophysical characterization, analytical testing, and data analysis to support formulation selection and developability assessments.
- Establish and run screening assays for oligonucleoProducts in early discovery, including formulation performance, solubility, viscosity, osmolality, degradation, , and stability assessments.
- Contribute to high-throughput and design-of-experiments approaches for formulation optimization, where applicable.
- Support long-term storage and stability evaluations for RNAi conjugates and oligonucleoProducts formulations.
- Maintain accurate experimental documentation and communicate findings through written summaries, reports, and internal presentations.
- Collaborate with internal stakeholders and external partners to support project deliverables and timelines.
- Identify technical gaps, propose practical solutions, and contribute to continuous improvement of formulation and characterization workflows.
- Thrive in a multidisciplinary, fast-paced research environment with competing priorities and tight deadlines.
Qualifications And Skills:
- MS with approximately 3 years of relevant experience, or PhD with 1-3 years of relevant experience in pharmaceutical sciences, formulation sciences, chemical engineering, biophysics, analytical chemistry, oligonucleoProducts delivery, or a related discipline.
- Hands-on experience with oligonucleoProducts or antibodies/proteins formulation and characterization is strongly preferred.
- Experience developing or running analytical methods for solubility, viscosity, osmolality, aggregation, , stability, or other developability assessments for complex oligonucleoProducts or antibody/protein formulations.
- Familiarity with automation, high-throughput screening, and DoE-based formulation optimization is an advantage.
- Strong experimental planning, documentation, data analysis, and problem-solving skills.
- Awareness of external trends and advances in RNA delivery, oligonucleoProducts therapeutics, and clinical translation is a plus.
- A track record of scientific contributions, publications, or conference presentations in relevant areas is a plus.
Additional Details
- City
- Lexington
- State
- Massachusetts
- Country
- US
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