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Kushal T. Kadakia, MSc, Malke Asaad, MD, Erica Adlakha, MS, Michael J. Overman, MD, Cristina M. Checka, MD, and Anaeze C. Offodile II, MD, MPH
Large pharma companies reduced headcounts by more than 22K in 2025 as $300B patent cliff looms
Large pharmaceutical companies, each with at least $20 billion in 2025 revenue, collectively reduced their workforces by more than 22,000 employees last year.
Among the 17 largest pharma companies analyzed in a Fierce Pharma review of annual reports, only five logged a head count increase in 2025*. In contrast, the immediate impact of job reductions on efficiency was evident: All but one company recorded growth in revenue per employee.
Pharma giants are apparently entering a correction phase in terms of size. Back in 2022, only three of the 17 firms we tracked recorded a workforce cutback.
This head count contraction comes as the biopharma industry braces for a massive $300 billion patent cliff in prescription drug revenues between 2025 and 2030. To maintain profits, many companies have resorted to cost cuts and layoffs. The trend wi
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